{
"@context": "https://schema.org",
"@graph": [
{
"@type": "WebPage",
"@id": "https://www.fortrea.com/insights/navigating-dynamic-study-design-hepatitis-b-research#webpage",
"url": "https://www.fortrea.com/insights/navigating-dynamic-study-design-hepatitis-b-research",
"name": "Navigating a dynamic study design in hepatitis B research",
"description": "This Fortrea case study explores how hepatitis B clinical trials were managed using a dynamic study design within a complex Phase II platform clinical trial. The study used an adaptive clinical trial design that allowed treatment arms and study drugs to be added or removed based on interim analysis data throughout the trial. The case study highlights challenges related to patient enrollment in clinical trials, maintaining site engagement during enrollment pauses, and coordinating protocol amendment approvals across participating sites. To support clinical trial operations, Fortrea implemented a collaborative clinical trial management approach focused on early engagement with sponsors, transparent communication with principal investigators, and ongoing coordination with site teams. By leveraging prior site experience from earlier hepatitis B research studies and maintaining continuous engagement across sites, the strategy supported operational continuity, enrollment readiness, and execution efficiency in a highly dynamic platform trial environment."
},
{
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "Home",
"item": "https://www.fortrea.com"
},
{
"@type": "ListItem",
"position": 2,
"name": "Insights",
"item": "https://www.fortrea.com/insights/"
},
{
"@type": "ListItem",
"position": 3,
"name": "Navigating a dynamic study design in hepatitis B research",
"item": "https://www.fortrea.com/insights/navigating-dynamic-study-design-hepatitis-b-research"
}
]
},
{
"@type": "Organization",
"@id": "https://www.fortrea.com/#organization",
"name": "Fortrea",
"url": "https://www.fortrea.com",
"description": "Fortrea is a global contract research organization built on more than 30 years of experience and one of the earliest CRO legacies in the industry—as Covance, evolving within Labcorp, and now operating as Fortrea. With deep expertise across Phase I–IV clinical trials, Fortrea advances clinical research through a patient-centric approach that prioritizes meaningful outcomes, stronger site–CRO relationships, and operational excellence. Fortrea partners with biopharmaceutical, biotech, and medical device companies to advance therapies through every stage of clinical development. This commitment is further reinforced by the launch of Fortrea Intelligent Technology, enabling smarter, more connected, and data-driven clinical development. Through Fortrea Intelligent Technology, the organization is advancing data-driven, technology-enabled clinical development to improve speed, quality, and patient outcomes. It is shaped by experience, innovation, and a commitment to raising standards in clinical research—focused on accelerating development and helping bring life-changing treatments to patients around the world.",
"logo": "https://www.fortrea.com/sites/default/files/2025-05/fortrea-logo-without-background.png",
"sameAs": [
"https://www.linkedin.com/company/fortrea",
"https://www.threads.net/@fortreacro",
"https://twitter.com/fortrea",
"https://www.youtube.com/@Fortrea/",
"https://www.facebook.com/Fortrea-104143099267108",
"https://www.instagram.com/fortreacro"
]
},
{
"@type": "Article",
"@id": "https://www.fortrea.com/insights/navigating-dynamic-study-design-hepatitis-b-research#casestudy",
"mainEntityOfPage": {
"@id": "https://www.fortrea.com/insights/navigating-dynamic-study-design-hepatitis-b-research#webpage"
},
"headline": "Hepatitis B Clinical Trials: Dynamic Platform Study Design | Fortrea Case Study",
"description": "This Fortrea case study explores how hepatitis B clinical trials were managed using a dynamic study design within a complex Phase II platform clinical trial. The study used an adaptive clinical trial design that allowed treatment arms and study drugs to be added or removed based on interim analysis data throughout the trial. The case study highlights challenges related to patient enrollment in clinical trials, maintaining site engagement during enrollment pauses, and coordinating protocol amendment approvals across participating sites. To support clinical trial operations, Fortrea implemented a collaborative clinical trial management approach focused on early engagement with sponsors, transparent communication with principal investigators, and ongoing coordination with site teams. By leveraging prior site experience from earlier hepatitis B research studies and maintaining continuous engagement across sites, the strategy supported operational continuity, enrollment readiness, and execution efficiency in a highly dynamic platform trial environment.",
"genre": "Case Study",
"image": {
"@type": "ImageObject",
"url": "https://www.fortrea.com/sites/default/files/2025-02/navigating-dynamic-study-design-in-hepatitis-b-research.jpg"
},
"author": {
"@type": "Organization",
"name": "Fortrea",
"url": "https://www.fortrea.com/"
},
"publisher": {
"@id": "https://www.fortrea.com/#organization"
},
"datePublished": "2025-02-05",
"dateModified": "2025-02-05",
"encoding": {
"@type": "MediaObject",
"contentUrl": "https://www.fortrea.com/sites/default/files/2025-02/navigating-dynamic-study-design-in-hepatitis-b-research.pdf",
"encodingFormat": "application/pdf"
}
}
]
}