Pulse Check: The Cardiovascular Conversations
Episode 1: Coronary Inflammation—The Next Frontier in Cardiovascular Risk Management
Description:
Despite advances in lipid-lowering and antithrombotic therapies, residual cardiovascular risk remains a major challenge. In this episode, Dr. Cheerag Shirodaria, Fortrea's cardiovascular lead, and Chris Farina, CEO of Abcentra, explore the emerging science behind coronary inflammation as a key driver of atherosclerotic disease. They discuss why inflammation, particularly in vulnerable coronary plaques, is gaining traction as a therapeutic target, and talk about Abcentra’s first-in-class monoclonal antibody - designed to selectively quell inflammation in diseased arterial tissue. With insights from landmark trials, and a look at how these new options differs from systemic anti-inflammatory agents, this episode offers a compelling case for a paradigm shift in cardiovascular drug development. If you're working in CV research, this is a must-listen.
Host: Dr. Cheerag Shirodaria, VP and Cardiovascular/Metabolic Therapeutic Area Head, Fortrea
Participant: Chris Farina, Abcentra CEO
References:
- Antonopoulos AS, Sanna F, Sabharwal N, et al. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017;9(398):eaal2658. doi:10.1126/scitranslmed.aal2658.
- Chan K, Wahome E, Tsiachristas A, et al. Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study. Lancet. 2024;403(10444):2606–2618. doi:10.1016/S0140-6736(24)00596-8.
- Claessen BE, Guedeney P, Gibson CM, et al. Lipid Management in Patients Presenting With Acute Coronary Syndromes: A Review. J Am Heart Assoc. 2023;12:e018897.
- Coronary Inflammation: The hidden driver of disease progression.
- Libby P, Hansson GK. Inflammation and immunity in diseases of the arterial tree: players and pathways. J Exp Med. 2022;219(6):e20211378.
- European Medicines Agency. Ilaris: EPAR – Product Information. London, UK: EMA; 2023.
- Farina C, Nilsson J, Gelfand JM, et al. Orticumab reduces coronary inflammation in patients with psoriasis: results from a Phase 2a randomized trial. Cardiovasc Res. 2024. Presented at: American College of Cardiology Annual Scientific Sessions; April 2024; Atlanta, GA.
- Farina et al, 2024, European Society of Cardiology, Cardiovascular Research March 25, 2024.
- Fauconnier A, Melis M, Berenbeck M, et al. Trends in the drug target landscape for autoimmune diseases. Nat Rev Drug Discov. 2025;24(4):245–248.
- Nidorf SM, Fiolet ATL, Mosterd A, et al. Colchicine in patients with chronic coronary disease. Lancet. 2020;396(10245):1181–1190. doi:10.1016/S0140-6736(20)31324-6.
- Oikonomou, E. K., Marwan, M., Desai, M. Y., et al. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP-CT study): A post-hoc analysis of prospective outcome data. The Lancet, 392(10151), 929–939. https://doi.org/10.1016/S0140-6736(18)31114-0.
- Ridker PM, Everett BM, Thuren T, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017;377(12):1119–1131.
- Tardif JC, Kouz S, Waters DD, et al. Efficacy and safety of low-dose colchicine after myocardial infarction. N Engl J Med. 2019;381(26):2497–2505. doi:10.1056/NEJMoa1912388.
- Virani SS, Alonso A, Aparicio HJ, et al. Heart Disease and Stroke Statistics—2023 Update: A Report from the American Heart Association. Circulation. 2023;147:e93–e621.
- Wockhardt UK Ltd. Colchicine 500 microgram Tablets: Summary of Product Characteristics. Electronic Medicines Compendium.